Endocrine Abstracts

Although over 50 type 2 diabetes (T2D) loci have been identified through genome-wide association studies (GWAS), the vast majority of the genetic predisposition to T2D still remains to be clarified. One explanation is that despite the use of high-throughput genotyping arrays, only a small proportion of genetic variants in the human genome are actually surveyed, especially in non-European populations. We explored the comprehensive catalog of genomic variations provided by the 1...

Aim: To clarify what arises from the decease of visceral adiposity in Japanese diabetic patients with visceral fat accumulation.Patients: Diabetic patients (n=30) whose visceral fat areas (V), determined with abdominal CT, were larger than 100 cm2.Methods: V was followed at every 6 month, and clinical profiles and course were compared of eight patients (group D), whose changes of V(ΔV=(<i...